You're not gonna be happy ... but then again, maybe you will be.
I ran your specs in Desktop Dyno, and it is usually pretty darned good. I had to infer your lift specs (I used .525") and lobe centers from a similar cam at Comp as yours don't show up on the site. I THINK the q-jets are 600 CFM but may be 650's, only make about 3 HP dif anyhow. I gave you the benefit of doubt on compression at 9:1. I'm running 8.5:1.
DD gives me back 336 HP @ 4500, 424 LbFt @ 3500. 339/426 with 660 CFM carbs.
Your exhaust system will give you fits from restrictiveness. Changing from my Niccson logs to Lightning headers will be good for right at 400 HP with a setup a bit hotter than yours (.565" lift, 280* duration, same heads, Performer RPM Air Gap manifold, 700 CFM Holley 4150).
Your holleys, 342HP/428'Q.
Big Chevys usually (but not always) seem to like a lot of timing. 35 to 36 degrees is very comon in good runners. That could net you a few ponies too as long as you stay away from detonation.
A big boost would be head-work by a pro shop. Porting a good set of large oval port heads (like 781's or 049's) is good for 70 to 80 HP according to the shop doing mine NEXT winter (headers this winter). I have 353049 heads.
A good porting, even with larger valves may only push you to 382HP/435Q due to your exhaust cramping you.
http://www.cpperformance.com They deal Lightning Headers, made for the big chevy, for both jets and I/O drives. look them over. They are fully water jacketed and are RELATIVELY inexpensive at $2,000 compared to other marine performance jacketed manifolds. Mufflered, with 4" outlets they boost your figures to 482HP/478Tq. 489/488 unmuffled.