Hands down get the new 6.0 Vortec max with the 345 HP, 385 Lbs torque over the 5.3.
Day and night over the 5.3 and gets 1-2 MPG better. Can run on regular as well, Premium for towing as in the 5.3 anyway. Worth every bit more. Do not get confused with the regular 6.0 be sure it is the vortec max.