The vacuum in your manifold will decrease when your secondaries open. With decreased vacuum, your vacuum advance distributor will not be as advanced as it was before the secondaries opened. When you step on the throttle, two butterflies open. The manifold pressure (vacuum) will be at a certain level. The distributor will be at a certain advance because of the vacuum. When the secondaries open, the pressure drop across the carburator will be less. As a result, vacuum will decrease. With less vacuum, your distributor will have less advance.
You can advance the base timing of the distributor or you can adjust the internals of the distributor to alter the advance curve. I don't know what will work best for you.
Good luck!!