Garry,
Watching my friend's problem from the sidelines I have a theory about what is happening. The boost referenced fuel pressure regulator only makes sure fuel can get into the bowl. I honestly believe the basic fuel metering function of the carb is being disrupted.
Since what causes fuel to be metered is the difference in air pressure between the air pressure acting on the fuel in the float chamber through the vent and the low pressure of the accelerated air in the venturi. The greater the difference of these two pressures the more fuel is metered. Normally high throttle position is where the most differential happens. We call this the "Fuel Metering Force" in aviation.
My Theory: Since the carb is enclosed in a box and the boost is being fed into this box. I think the pressure differential required to meter fuel is being severely reduced causing a reduced fuel flow. Jetting does not matter if there is not suffecient pressure differential to push fuel through the jets.
When boost rises, I believe the pressures in the manifold, box, and float chamber are very close and preventing proper fuel metering. I think the air velocity pressure drop in the venturi is being offset by the pressure in the enclosed carb box. It seems to me at high throttle position the boost presure is the same from the intake valve all the way back to the procharger compressor. This will mean the pressure in the float chamber is too close to the pressure in the venturi. The engine will lean out regardless of fuel pressure or jetting.
Whew -- Any comments?