The cylinder de-activation is strictly to obtain better mileage.
When cruising at a steady speed, or decelerating, or going downhill, the onboard computer cuts fuel and spark to 2 or 4 cylinders (depending on the style). When needed for acceleration or going up hills, all 8 cylinders kick in.
I have that on my 2007 Tahoe, and the transition is seamless. You can't tell when it switches.
On a recent trip, the display read from 18 MPG in 8 cylinder mode to 36 MPG in 4 cylinder mode, going on a straight road with gradual dips.