We had a guy take 4 of these in the ten ring, go down, and then sit up and fire again. Three more to the temple stopped that threat.
That's one of a hundred reasons I could never be a cop. Of the first four shots, two would have been in the head anyway, and one would have been considered a "security" round...
When I bought the Cor-Bon +p rounds for Audrey's .45, the guy in the range saw that Aud was practicing mozambique drills and casually informed her that a Cor-Bon +P hit so hard that you would have a tough time finding a second piece big enough to aim at after the first shot.