The answer is-it depends. Depends on part selection & power output as much as it does your driving style. If you have a stock merc motor I think the 400-450 hour marks are conservative and as long as you aren't a leadfoot they should run for atleast that long.
The higher output motors I would say will get a refreshin fewer hours, not because they cant handle it but because they get pushed harder because they can handle it, thus wearing them out faster.Its cheaper to freshen a high output motor than it is to do a complete rebuild.