The biggest problem with your quest for 1000hp on pump gas will be heat.Therefore,a good aluminum head(ported and matched) and a high capacity intercooler will be mandatory,and I would recommend a 14-71 blower.Teague Marine's 1000HP produces the power at 6000RPM with a 14-71.Also,a hydraulic roller is the only way to go for a cam.It requires a high dollar valvetrain but it is the only way to go.(Obviously make sure it's matched to your combo/drive)If I were you I would consult every engine builder within reach for advice.Finally,make sure your reciprocating assembly is ready for the HP!!!